Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis
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چکیده
منابع مشابه
Identification and characterization of the plasma kallikrein-kinin system inhibitor, haemaphysalin, from hard tick, Haemaphysalis longicornis.
The plasma kallikrein-kinin system inhibitor, haemaphysalin, from the hard tick, Haemaphysalis longicornis, was identified. It was found that haemaphysalin inhibited activation of the plasma kallikrein-kinin system by interfering with reciprocal activation between factor XII and prekallikrein. It did not, however, inhibit amidolytic activities of factor XIIa and kallikrein. Direct binding assay...
متن کاملVaccination effects of recombinant chitinase protein from the hard tick Haemaphysalis longicornis (Acari: Ixodidae).
The success of immunological method for the control of ticks depend on the use of potential key antigens as tick vaccine candidates. Chitinase is induced by ecdysteroids to degrade the older chitin at the time of molting. Previously, we cloned a gene encoding 113 kDa protein (CHT1) of Haemaphysalis longicornis, and identified the CHT1 as a protein of chitinase (You et al. 2003). In this study, ...
متن کاملProteomic Screening of Antigenic Proteins from the Hard Tick, Haemaphysalis longicornis (Acari: Ixodidae)
Proteomic tools allow large-scale, high-throughput analyses for the detection, identification, and functional investigation of proteome. For detection of antigens from Haemaphysalis longicornis, 1-dimensional electrophoresis (1-DE) quantitative immunoblotting technique combined with 2-dimensional electrophoresis (2-DE) immunoblotting was used for whole body proteins from unfed and partially fed...
متن کامل1 Antibacterial activity by hemolymph defensin from 2 the hard tick Haemaphysalis longicornis 3
Ticks are key vectors of some important diseases of humans and animals. Although they 21 are carriers of disease agents, the viability and development of ticks are not harmed by the infectious 22 agents due to their innate immunity. Antimicrobial peptides directly protect hosts against 23 pathogenic agents such as viruses, bacteria, and parasites. Among the identified and characterized 24 antim...
متن کاملMultiple ferritins are vital to successful blood feeding and reproduction of the hard tick Haemaphysalis longicornis.
Ticks are obligate hematophagous parasites and important vectors of diseases. The large amount of blood they consume contains great quantities of iron, an essential but also toxic element. The function of ferritin, an iron storage protein, and iron metabolism in ticks need to be further elucidated. Here, we investigated the function a newly identified secreted ferritin from the hard tick Haemap...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2017
ISSN: 1756-3305
DOI: 10.1186/s13071-017-2397-9